| Insert |
DNA: genomic Insert lengths(kb): 15.80000019073486 Tissue: D-PLL cell line (B-prolymphocytic leukemia) Gene product: T cell receptor, gamma, constant region C1 [TCRGC1] Alleles: B1, D4, J2, D2, A1, A2, B2, G1, G2, J1, D1, D3 |
| Comments |
Restriction digests of the clone give the following sizes (kb): XbaI--20.0, 11.0, 9.2, 3.2, 2.4; SacI--20.0, 9.2, 6.2 (doublet), 4.4; XhoI--20.0, 11.0, 9.2, 3.2, 3.1; SmaI--20.0, 11.0, 6.0, 5.8, 3.7; PvuI--23.0, 12.0, 8.2. Contains germline DNA beginning about 1.9 kb upstream of Cgamma1 exon 2 and extending about 1.4 kb beyond Cgamma2 exon 1. Contains the allele with the polymorphic HindIII site in Jgamma2 missing. Additional GenBank/EMBL accession numbers: M14997, M14998, M15002, X03435. |
| References |
Lefranc MP, Rabbitts TH. Two tandemly organized human genes encoding the T-cell gamma constant-region sequences show multiple rearrangement in difference T-cell types. Nature 316: 464-466, 1985. PubMed: 2991773
Lefranc MP, et al. Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene gamma. Proc. Natl. Acad. Sci. USA 83: 9596-9600, 1986. PubMed: 2879283
Marie-Paule Lefranc, personal communication
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