| Comments |
Restriction digests of the clone give the following sizes (kb): EcoRI--3.8, 3.0; NotI--3.8, 3.0; BamHI--5.5, 1.3; PstI--4.3, 2.5; PvuII--2.5, 2.2, 1.05, 0.6, 0.45. The insert contains the following restriction sites (approximate kb from the 5' end): BamHI--1.12; PstI--2.43, 2.46; SalI--2.65; PvuII--2.51, 2.92. Encodes the isoform produced from 4.0 and 6.5 kb transcripts. Contains the complete coding sequence (nt 627-3305). Corresponds exactly to GenBank accession L12376. |
| References |
Van de Ven WJ, et al. Furin: the prototype mammalian subtilisin-like proprotein-processing enzyme. Endoproteolytic cleavage at paired basic residues of proproteins of the eukaryotic secretory pathway. Enzyme 45: 257-270, 1991. PubMed: 1843280
Roebroek AJ, et al. Generation of structural and functional diversity in furin-like proteins in Drosophila melanogaster by alternative splicing of the Dfur1 gene. EMBO J. 12: 1853-1870, 1993. PubMed: 8491178
Wim J Van De Ven, personal communication
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