| Comments |
Restriction digests of the clone give the following sizes (kb): EcoRI/HindIII--4.2, 2.85; BamHI--7.2; PvuII--4.6, 2.3. Linkage has been established between D15S1 and Marfan syndrome in 17 families (theta = 0, LOD score = 8.114). Enzyme(s) not detecting polymorphism: MboI, TaqI, EcoRI, HindIII, BamHI, KpnI, PvuII, BglII, HincII, PstI, SstI, XmaI, HaeIII, BstNI, BstEII, AccI, StuI, RsaI, AluI, SinI, HinfI, XbaI, DdeI, NaeI. |
| References |
Nakamura Y, et al. A mapped set of DNA markers for human chromosome 15. Genomics 3: 342-346, 1988. PubMed: 3243548
Barker D, et al. Restriction sites containing CpG show a higher frequency of polymorphism in human DNA. Cell 36: 131-138, 1984. PubMed: 6198090
Kainulainen K, et al. Marfan syndrome: no evidence for heterogeneity in different populations, and more precise mapping of the gene. Am. J. Hum. Genet. 49: 662-667, 1991. PubMed: 1882844
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