This panel is useful for PTEN pathway and PI3K pathway research and for anti-cancer drug discovery.
Biosafety Level
1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
Comments
PTEN is a tumor suppressor gene that encodes for a lipid phosphatase protein that down-regulates PI3K activity, which in turn affects the AKT signaling pathway and regulation of the cell cycle. Mutations in this gene are associated with a variety of cancers, including brain, skin and ovarian.
The PTEN genetic alteration cell panel (ATCC TCP-1030) is composed of ten human tumor cell lines from common cancer types that carry PTEN mutations or PTEN deletions. The PTEN status of each cell line has been sequenced and validated by ATCC. This panel is useful for PTEN and PI3K pathway research and for anti-cancer drug discovery.
