| Components |
KASUMI-1, ATCC CRL-2724
HL-60, ATCC CCL-240
THP-1, ATCC TIB-202
K-562, ATCC CCL-243
RS4;11, ATCC CRL-1873
MOLT-4, ATCC CRL-1582
CCRF-CEM, ATCC CCL-119 |
| Applications |
Biological understanding of top genetic alterations in leukemia Validation and characterization of potential cancer driver genes Functional profiling and molecular profiling of subtype-specific cancer cell lines Testing small molecules or biologics for cancer drug development |
| Comments |
A panel of 7 leukemia cell lines representing Acute Myeloid Leukemia (AML), Acute Monocytic Leukemia (AMoL), Chronic Myeloid Leukemia (CML), and Acute Lymphoblastic Leukemia (ALL). Each culture contains genomic mutations in one or more of the following genes according to the Sanger COSMIC database: CDKN2A, KDM6A, TP53, NRAS, NOTCH1, PTEN, FBXW7, FLT3, KRAS, MLH1, and PIK3R1. |
