| Comments |
Restriction digests of the clone give the following sizes (kb): EcoRI--21.0, 13.0, 8.8 (doublet); HindIII--23.0, 15.0, 8.8, 6.0; BamHI--21.0, 12.0, 7.6, 6.0, 4.0; BglII-->23.0, 5.6; SmaI-->23.0, 9.4 (doublet), 5.0. D6S21 has been localized to 6q27 on the human chromosome. The RsaI polymorphism is also detected by HindIII, HaeIII, MspI, TaqI, ApaI, BstEII, StyI, BglII, BamHI, EcoRI and HincII. |
| References |
Schumm JW, et al. Identification of more than 500 RFLPs by screening random genomic clones. Am. J. Hum. Genet. 42: 143-159, 1988. PubMed: 2892396
Donis-Keller H, et al. A genetic linkage map of the huma genome. Cell 51: 319-337, 1987. PubMed: 3664638
Kazazian HH Jr., et al. Characterization of a spontaneous mutation to a B-thalassemia allele. Am. J. Hum. Genet. 38: 860-867, 1986. PubMed: 3014870
Knowlton RG, et al. Use of highly polymorphic DNA probes for genotypic analysis following bone marrow transplantation. Blood 68: 378-385, 1986. PubMed: 3524708
Weiffenbach B, et al. Single copy probe CRI-L1065 (D6S21) maps to 6cen-6q21. Nucleic Acids Res. 19: 199, 1991. PubMed: 1672748
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