| Insert |
DNA: cDNA Insert lengths(kb): 1.25 Tissue: fetal brain Gene product: Hardy-Zuckerman 4 feline sarcoma viral (v-kit) oncogene homolog( Mast cell growth factor, c-kit proto-oncogene protein) [W] Alleles: A1, A2, B1, B2, , |
| Comments |
Restriction digests of the clone give the following sizes (kb): EcoRI--3.7, 0.72; BamHI--3.2, 1.2; PstI--4.4; HindIII--3.5, 0.9; SalI--3.2, 1.2; NotI--uncut. Detects human genomic restriction fragments of the following sizes (kb): NotI--750, EagI--450, 225; SalI--550, 500, 300; XhoI--225, 125; NruI--greater than 2200. Insert includes some 5' untranslated sequence and the 5' end of the 4 kb gene. It encodes part of the extracellular domain of a 145 kDa membrane protein. |
| References |
Hsieh CL, et al. Chromosomal localization of the gene for AA-type platelet-derived growth factor receptor (PDGFRA) in humans and mice. Cytogenet. Cell Genet. 56: 160-163, 1991. PubMed: 1711435
Yarden Y, et al. Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J. 6: 3341-3351, 1987. PubMed: 2448137
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