| 產品名稱 |
B0.7 [p528B0.7] |
| 商品貨號 |
B239471 |
| Designations |
B0.7 [p528B0.7] |
| Species |
Homo sapiens, human |
| Depositors |
Temple University, CM Croce, Temple University |
| Applications |
Has been used to detect t(1;14)(p32;q11) translocations associated with certain acute T-cell leukemias based on the size of the EcoRI fragment detected. |
| Vector |
Construct size (kb): 3.400000095367432 |
| Insert |
DNA: genomic Insert lengths(kb): 0.699999988079071 Tissue: acute T-lymphoblastic leukemia DU.528 cell line Gene product: T-cell acute lymphocytic leukemia 1 (NOTE: redefinition of symbol)(T cell lymphoma 5, helix-loop-helix protein tal-1, 34 kDa) [TAL*] |
| Insert Size (kb) |
0.700 |
| Biosafety Level |
1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Comments |
Restriction digests of the clone give the following sizes (kb): BamHI--2.6, .72; EcoRI--3.7; HindIII--3.7. Derived from a germ-line fragment that includes what would be the 1p+ translocation breakpoint in the DU.528 cell line. Detects a human genomic germline EcoRI fragment of 17.5 kb. Has been used to detect t(1;14)(p32;q11) translocations associated with certain acute T-cell leukemias based on the size of the EcoRI fragment detected. Detects transcripts of 5.4, 2.6, and 2.2 kb from TAL1 (TCL5). |
| References |
Croce CM. TCL-5 gene rearrangement involved in T-cell leukemia and melanoma. US Patent 5,242,795 dated Sep 7 1993
Finger LR, et al. Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc. Natl. Acad. Sci. USA 86: 5039-5043, 1989. PubMed: 2740341
|
| Disclosure |
This material is cited in a US or other Patent and may not be used to
infringe the claims. Depending on the wishes of the Depositor, ATCC may be
required to inform the Patent Depositor of the party to which the material was
furnished. This material may not have been produced or characterized by ATCC. |
